Bioorganic & medicinal chemistry

Synthesis and cytotoxicity evaluation of novel indolylpyrimidines and indolylpyrazines as potential antitumor agents

B Jiang, CG Yang, WN Xiong, J Wang

Index: Jiang, Biao; Yang, Cai-Guang; Xiong, Wen-Nan; Wang, Jun Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 5 p. 1149 - 1154

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Citation Number: 113

Abstract

Novel indolylpyrimidines and indolylpyrazines have been synthesized as potential antitumor agents. They were screened in a panel of 60 human tumor cell lines in vitro. Compounds 7, 9, 10, 15, 21 exhibited efficiently cytotoxic activities with GI50 values in the low micromolar range against a variety of human cancer cell lines. 2, 4-Bis (3′-indolyl) pyrimidine 8 displayed selective cytotoxic activity against IGROV1 tumor cell line with the GI50 value ...