Improved and Efficient Process for the Production of Highly Pure Iloperidone: A Psychotropic Agent

PV Solanki, SB Uppelli, BS Pandit…

Index: Solanki, Pavankumar V.; Uppelli, Sekhar Babu; Pandit, Bhushan S.; Mathad, Vijayavitthal T. Organic Process Research and Development, 2014 , vol. 18, # 2 p. 342 - 348

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Citation Number: 5

Abstract

The present work describes an improved and highly efficient process for the synthesis of iloperidone (1), an antipsychotic agent, which is free from potential impurities. The synthesis comprises N-alkylation of 1-(4-(3-chloropropoxy)-3-methoxyphenyl) ethanone (4) with 6- fluoro-3-piperidin-4-yl-1, 2-benzisoxazole hydrochloride (5) in a mixture of water and heptane as solvent and sodium hydroxide as a base in the presence of ...