Discovery of substituted 2, 4, 4-triarylimidazoline derivatives as potent and selective neuropeptide Y Y5 receptor antagonists

N Sato, M Jitsuoka, S Ishikawa, K Nagai…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 6 p. 1670 - 1674

Full Text: HTML

Citation Number: 10

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... 11. Our in-house chemical collection was screened against the human Y5 receptor, resulting in the identification of 2,4,4-triphenylimidazoline (1). Subsequently, the 2-phenyl portion was extensively optimized to identify several potent ...