Evaluation of cis-and trans-9-and 11-hydroxy-5, 6, 6a, 7, 8, 12b-hexahydrobenzo [a] phenanthridines as structurally rigid, selective D1 dopamine receptor ligands

WK Brewster, DE Nichols, VJ Watts…

Index: Brewster, William K.; Nichols, David E.; Watts, Val J.; Riggs, Robert M.; Mottola, Dave; Mailman, Richard B. Journal of Medicinal Chemistry, 1995 , vol. 38, # 2 p. 318 - 327

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Citation Number: 15

Abstract

The present study reports the investigation of the D1 structure-relationships of certain cis-or trans-9-or 1 1-monohydroxy analogues of (f)-trans-10, 11-dihydroxy-5, 6, 6a, 7, 8, 1 2b- hexah y-drobenzo [a] phenanthridine (8a, dihydrexidine), previously identified as the first full efficacy D1 dopamine receptor agonist. The monohydroxybenzo [alphenanthridines were prepared from the appropriately substituted B-tetralones using the methods described ...