Synthetic Communications®

Simple, Novel Synthesis for 1-Carbamoyl-l H-benzotriazole and Some of Its Analogs

CJ Perry, K Holding, E Tyrrell

Index: Perry, Christopher John; Holding, Keith; Tyrrell, Elizabeth Synthetic Communications, 2008 , vol. 38, # 19 p. 3354 - 3365

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Citation Number: 6

Abstract

Abstract 1-Carbamoyl-1 H-benzotriazole (benzotriazole-1-carboxamide, 2a), an effective carbamoyl chloride substitute, and a range of its analogs can be synthesized in good yields in two very simple steps from 1, 2-diaminobenzene. The facile preparation of the intermediate o-aminophenylurea is key to this process. A preliminary study of the reactivity of 2a has shown that once in solution in tetrahydrofuran (THF), the 1-carbamoyl isomer ...