Journal of medicinal chemistry

Preparation and evaluation of 2-substituted anthraquinones based on the anthracyclines

S Bennett, D Sharples, JR Brown

Index: Bennett, Stephen; Sharples, Derek; Brown, Jeffrey R. Journal of Medicinal Chemistry, 1982 , vol. 25, # 4 p. 369 - 373

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Citation Number: 10

Abstract

Conclusions The changes in the spectral properties of compounds 13-24 on interaction with DNA and the effects of these compounds on the thermal denaturation of DNA are consistent with an intercalative mode of interaction. The 1, 4-dihydroxyanthraquinones 13-17 have a greater affinity for DNA than do the 1-hydroxy and nonhydroxylated compounds 18-24, and there is greatest activity where there are five atoms between the ring system and the basic ...