Tetrahedron

The mannich reaction-II: Derivatization of aldehydes and ketones using dimethyl (methylene) ammonium salts

N Holy, R Fowler, E Burnett, R Lorenz

Index: Holy,N. et al. Tetrahedron, 1979 , vol. 35, p. 613 - 619

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Citation Number: 55

Abstract

Aldehydes and ketones have been converted efficiently to their corresponding Mannich products by various dimethyl (methylene) ammonium salts under a range of reaction conditions. The several methods used to form these derivatives are compared. Excellent approaches to aldehyde derivatives involve treating the enol silyl ether of the carbonyl compound with methyllithium and then an iminium salt, or directly adding the iminium salt ...