Tetrahedron Letters

Synthesis of novel prostaglandins containing a boronate in the α chain

Z Feng, M Hellberg

Index: Feng, Zixia; Hellberg, Mark Tetrahedron Letters, 2000 , vol. 41, # 31 p. 5813 - 5816

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Citation Number: 8

Abstract

Many prostaglandin derivatives have been synthesized in an attempt to develop therapeutic agents during the past decades. Recently, much of this effort has centered on the identification of prostaglandin derivatives as ocular hypotensives for the use in the treatment of glaucoma. 1 In this paper, we report the successful synthesis of a novel class of prostaglandin in which the carboxylic acid is replaced by boronic acid ester (Scheme 1).