The Journal of Organic Chemistry

The Mechanism of Action of Bisalkylating Agents in Cancer Chemotherapy. II. The Reaction of Myleran with Mercaptans1

WE PARHAM, JM WILBUR Jr

Index: Parham,W.E.; Wilbur,J.M. Journal of Organic Chemistry, 1961 , vol. 26, p. 1569 - 1572

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Citation Number: 10

Abstract

It is unreasonable to assume that XVII is formed by either an SN-1 or SN-2 reaction of mercaptide at CZ (in XV) in view of the results previously obtained with butyl and methyl mercaptan, and incompatible with the previous observation that the reaction of myleran with the sodium salt of cysteine ethyl ester affords VI.