Tetrahedron: Asymmetry

Synthesis of novel chiral oxazoline ligands and application in the highly enantioselective diethylzinc addition to N-diphenylphosphinoylimines

G Yan, Y Wu, W Lin, X Zhang

Index: Yan, Gexin; Wu, Yong; Lin, Wenqing; Zhang, Xiaomei Tetrahedron Asymmetry, 2007 , vol. 18, # 22 p. 2643 - 2648

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Citation Number: 17

Abstract

Two sets of novel chiral oxazoline ligands were designed and conveniently prepared from readily available l-aspartic acid and evaluated in enantioselective diethylzinc addition to N- diphenylphosphinoyl imines. In the presence of stoichiometric amounts of these ligands, high enantioselectivities (up to 95% ee) and yields (up to 85%) were achieved for several aromatic imines in toluene at room temperature. Furthermore, the effect of the structure of ...