Xenobiotica

Prediction of metabolic clearance using fresh human hepatocytes: comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines

D Hallifax, A Galetin, JB Houston

Index: Xenobiotica, , vol. 38, # 4 p. 353 - 367

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Citation Number: 24

Abstract

... 200338. ... Xenobiotica 2005; 35: 603–625 View all references) and cryopreserved hepatocytes (Hallifax et al. ... cases, this was maximal at the lowest testosterone concentration (5 µM) (Figure 2). The magnitude of this effect was greater, on average, for the 4-hydroxylation pathway ...