Novel Tn antigen-containing neoglycopeptides: synthesis and evaluation as anti tumor vaccines

…, M Rescigno, A Leone, F Peri, B La Ferla…

Index: Cipolla, Laura; Rescigno, Maria; Leone, Antonella; Peri, Francesco; La Ferla, Barbara; Nicotra, Francesco Bioorganic and medicinal chemistry, 2002 , vol. 10, # 5 p. 1639 - 1646

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Citation Number: 60

Abstract

The fully unprotected α-C-glycosyl analogue of N-acetylgalactosamine 9 was conjugated by a non-natural oxime bond to the segment peptides 328–340OVA and 327–339OVA, affording neoglycopeptides 1–2 and 3, having one or two sugar units, respectively. The three neoglycopeptides were tested in vitro in an antigen presentation assay as antitumor vaccines. Neoglycopeptides 1–3 could be presented to and recognized by the T cell ...