Selective phenol alkylation: an improved preparation of efaproxiral

…, R Davis, RN Fitzgerald, JM Haberman

Index: Anderson, Joanne; Davis, Roman; Fitzgerald, Russ; Haberman, Jannine Synthetic Communications, 2006 , vol. 36, # 15 p. 2129 - 2133

Full Text: HTML

Citation Number: 13

Abstract

Abstract An improved, two??step synthesis of efaproxiral, used in breast cancer therapy, is described, utilizing inexpensive commodity chemicals for starting materials. Selective amide formation and O??alkylation in the presence of multireactive functional groups is demonstrated, thus avoiding protection/deprotection steps.