Analgesic dipeptide derivatives. 3. Synthesis and structure-activity relationships of o-nitrophenyl-modified analogs of the analgesic compound H-Lys-Trp (NPS)-OMe

MT Garcia-Lopez, R Gonzalez-Muniz…

Index: Garcia-Lopez, M. Teresa; Gonzalez-Muniz, Rosario; Molinero, M. Teresa; Naranjo, Jose R.; Rio, J. Del Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1658 - 1663

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Citation Number: 11

Abstract

A series of analogues of the analgesic dipeptide derivative H-Lys-Trp (NPS)-OMe has been designed to determine the influence of the (2-nitropheny1) sulfenyl (NPS) moiety on the activity. The syntheses and antinociceptive effects of these analogues of general formula H- Lys-Trp (R)-OMe [R= phenylsulfenyl (PS)(9); R=(2-carbomethoxypheny1) sulfenyl (CmPS)(10); R=(4-nitropheny1) sulfenyl (pNPS)(1 1); R=(2, 4-dinitrophenyl) sulfenyl ( ...