Optimization of triazoles as novel and potent nonphlorizin SGLT2 inhibitors

X Du, M Lizarzaburu, S Turcotte, T Lee…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 12 p. 3774 - 3779

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Citation Number: 8

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Previous efforts have led to the identification of a potent, selective, and nonphlorizin based SGLT2 inhibitor 1. This Letter describes efforts to further optimize the potency, microsomal stability, solubility and pharmacokinetic properties ...

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