Design, synthesis and RNase A inhibition activity of catechin and epicatechin and nucleobase chimeric molecules

…, S Dutta, A Chowdhary, A Basak, S Dasgupta

Index: Roy, Basab; Dutta, Sansa; Chowdhary, Anupma; Basak, Amit; Dasgupta, Swagata Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5411 - 5414

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Citation Number: 10

Abstract

Several novel catechin/epicatechin and nucleobase chimeric molecules 1–6 have been synthesized via azide-alkyne click chemistry. The structures of these hybrids have been confirmed by NMR and mass spectroscopic data. The synthesized molecules were tested for their RNase A inhibition activities. Gel-based assays showed inhibition in micromolar concentrations. The extent of inhibition was found to be dependent upon the nature of ...