A thienopyridazinone-based melanin-concentrating hormone receptor 1 antagonist with potent in vivo anorectic properties

B Dyck, S Markison, L Zhao, J Tamiya…

Index: Journal of Medicinal Chemistry, , vol. 49, # 13 p. 3753 - 3756

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Citation Number: 36

Abstract

... Journal of Medicinal Chemistry. ... Alkynyl-substituted chloropyridazinones have previously been described in the synthesis of furan, pyrrole, and thiophene-fused derivatives, and by using in situ generated sodium selenide, we have extended this chemistry to the selenophene. ...