A Mild and Efficient Method for the Deformylation of 5-Formyl Uracils and Synthesis of 4, 4′-Methylidenebis (1-phenyl-3-methyl-5-pyrazolone)

ML Deb, S Majumder, PJ Bhuyan

Index: Deb, Mohit L.; Majumder, Swarup; Bhuyan, Pulak J. Synlett, 2009 , # 12 p. 1982 - 1984

Full Text: HTML

Citation Number: 1

Abstract

6-Hydroxy- and 6-aminouracils are two important classes of functionalized uracils. [4] 6-Hydroxyuracils constitute the basic moiety of clinically used hypnotic drugs of the barbiturates class, such as veronal, seconal, and phenobarbital. 6-Aminouracils are the key intermediates in the synthesis of purines, which constitute the basic moiety of a number of drugs, including caffeine, penciclovir, theobromine and theophylline. Moreover, 6-hydroxy- and 6-aminouracils find ...