Chemical Communications

Enantioselective synthesis and application of the highly fluorescent and environment-sensitive amino acid 6-(2-dimethylaminonaphthoyl) alanine (DANA)

M Nitz, AR Mezo, MH Ali, B Imperiali

Index: Nitz, Mark; Mezo, Adam R; Ali, Mayssam H; Imperiali, Barbara Chemical communications (Cambridge, England), 2002 , # 17 p. 1912 - 1913

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Citation Number: 27

Abstract

PRODAN has been used as a probe in many biological systems, perhaps most notably in the study of lipid bilayers 4 and in proteins which have a fortuitous binding site for the fluorophore. 5 Derivatives of PRODAN have also been attached covalently to proteins via reaction with amino acid side chain thiols with 6-acryloyl-2-(dimethylamino)naphthalene 6,7 or 6-bromoacetyl-2-dimethylaminonaphthalene (BADAN). 8 These methods provided useful ...