Molecules

One-Pot Chemoenzymatic Multicomponent Synthesis of Thiazole Derivatives

H Zheng, YJ Mei, K Du, XT Cao, PF Zhang

Index: Zheng, Hui; Mei, Yi-Jia; Du, Kui; Cao, Xian-Ting; Zhang, Peng-Fei Molecules, 2013 , vol. 18, # 11 p. 13425 - 13433

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Citation Number: 6

Abstract

Abstract: A novel chemoenzymatic one-pot multicomponent synthesis of thiazole derivatives was developed. A series of thiazole derivatives were synthesized with high yields up to 94% under mild enzyme-catalyzed conditions. The blank and control experiments reveal that trypsin from porcine pancreas (PPT) displayed great catalytic activity to promote this reaction and showed a wide tolerance range towards different substrate amines. This trypsin- ...