Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors

M Ichikawa, A Yokomizo, M Itoh, K Sugita…

Index: Bioorganic and Medicinal Chemistry, , vol. 19, # 6 p. 1930 - 1949

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Citation Number: 14

Abstract

... Bioorganic & Medicinal Chemistry. ... trend, statins have become increasingly recognized as an imperfect medicine for all types of hypercholesterolemia, and an alternative antihyperlipidemic agent which does not inhibit isoprenoid biosynthesis is desired in medical practice. ...