Inactivation of Amino Acid Racemase by S-(N-Methylthio-carbamoyl)-d, l-cysteine

T Kimura, N Esaki, H Tanaka, K Soda

Index: Kimura, Tomio; Esaki, Nobuyoshi; Tanaka, Hidehiko; Soda, Kenji Agricultural and Biological Chemistry, 1984 , vol. 48, # 2 p. 383 - 388

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Citation Number: 7

Abstract

S-(N-Methylthiocarbamoyl)-d-and l--cysteine (MTCC) are new irreversible inhibitors of the amino acid racemase from Pseudomonas putida. Interactions between d-or l-MTCC and purified amino acid racemase were investigated. The racemase catalyzes not only racemization reactions of d-and l-MTCC but also their αβ, elimination reactions with concomitant inactivation. This inactivation exhibits the characteristics of suicide inhibition, ...