Research on Chemical Intermediates

Isolation of highly pure erlotinib hydrochloride by recrystallization after nucleophilic substitution of an impurity with piperazine

G Zhang, L Zha

Index: Zhang, Gengzhen; Zha, Linlin Research on Chemical Intermediates, 2013 , vol. 39, # 6 p. 2303 - 2309

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Citation Number: 2

Abstract

Abstract Optimized synthesis and purification of erlotinib hydrochloride (N-(3-ethynylphenyl)- 6, 7-bis (2-methoxyethoxy) quinazoline-4-amine hydrochloride) were studied. Highly polar piperazine was used in a nucleophilic substitution reaction with the chlorinated intermediate