Pyridazines. XXIII. A novel pyridazine into pyrazole ring transformation

G Heinisch, R Waglechner

Index: Heinisch, Gottfried; Waglechner, Richard Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 1727 - 1731

Full Text: HTML

Citation Number: 16

Abstract

Abstract Treatment of phenyl (4-pyridazinyl) methanols 1a and 1b with p-toluenesulfonic acid at elevated temperatures causes transformation into the C-4 substituted pyrazole derivatives 8a and 8b. Limitations of this novel rearrangement reaction as well as mechanistic considerations are discussed. Furthermore, the preparation of hitherto unknown 4-pyridazinylmethanols 1b, 3, and 7 is described.