Concise Synthesis of Pelanserine, Goshuyuamide II, and Wuchuyuamide II with Quinazolinedione Nuclei

X Li, YR Lee, SH Kim

Index: Li, Xin; Lee, Yong Rok; Kim, Sung Hong Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 9 p. 3480 - 3482

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Abstract

Quinazolinediones are important heterocycles 1 and have been shown to possess pharmacologically interesting properties, displaying, for example, anti-hypertensive, 2 antidiabetic, 3 and immunosuppressive activities. 4 Among these, synthetic pelanserine (TR2515)(1) 5 is a well established potent anti-hypertensive agent, having activity comparable to the clinically used ketanserin 6 (Figure 1). Goshuyuamide II (2) is isolated ...