New σ and 5-HT1A receptor ligands: ω-(tetralin-1-yl)-n-alkylamine derivatives

…, G Giudice, R Perrone, V Tortorella…

Index: Berardi; Colabufo; Giudice; Perrone; Tortorella; Govoni; Lucchi Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 176 - 182

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Citation Number: 39

Abstract

Two series of compounds that are structurally related to benzomorphans, derived by structural modification of arylpiperazines with high 5-HT1A affinity and moderate σ affinity, were prepared in order to increase σ affinity and selectivity. All new compounds are N- substituted-ω-(1, 2, 3, 4-tetrahydronaphthalen-1-yl)-or-ω-(1, 2-dihydronaphthalen-4-yl)-n- alkylamines with, in some cases, a methoxy group on the tetralin moiety. They were tested ...