Synthesis of 5??(Fluorophenyl) tocopherols as Novel Dioxin Receptor Antagonists
E Kloser, S Böhmdorfer, L Brecker…
Index: Kloser, Elisabeth; Boehmdorfer, Stefan; Brecker, Lothar; Kaehlig, Hanspeter; Netscher, Thomas; Mereiter, Kurt; Rosenau, Thomas European Journal of Organic Chemistry, 2011 , # 13 p. 2450 - 2457
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Citation Number: 7
Abstract
Abstract γ-Tocopherol, a component of the essential nutrient mixture commonly designated as vitamin E, was chemically combined with differently substituted monofluoro-and difluorophenyl moieties to produce potential antagonists for the human aryl hydrocarbon receptor (AhR). 5-Iodo-γ-tocopherol was a very reliable starting material for the Pd-catalyzed reaction with (fluorophenyl) boronic acids (Suzuki coupling). The ortho-and meta-fluoro- ...
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