Synthesis of 25-hydroxycholecalcifer-16-en-23-ynol: a potential antipsoriatic agent
M Okabe, RC Sun, M Scalone, CH Jibilian…
Index: Okabe; Sun; Scalone; Jibilian; Hutchings Journal of Organic Chemistry, 1995 , vol. 60, # 3 p. 767 - 771
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Citation Number: 24
Abstract
It has been shown that la, 25-dihydroxycholecalciferol (1) lJ or its analogs [1a- hydroxycholecalciferol, 2a la, 24-dihydroxycholecalciferol, 3 calcipotriol I have beneficial therapeutic effects in psoriasis, a hyperproliferative skin di~ order.~ However, their clinical use may be limited by
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