Target-Specific Ligands and Gadolinium-Based Complexes for Imaging of Dopamine Receptors: Synthesis, Binding Affinity, and Relaxivity

I Zigelboim, A Weissberg, Y Cohen

Index: Zigelboim, Isaac; Weissberg, Avi; Cohen, Yoram Journal of Organic Chemistry, 2013 , vol. 78, # 14 p. 7001 - 7012

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Citation Number: 7

Abstract

Magnetic resonance imaging (MRI) and positron emission tomography (PET) are two extremely important imaging modalities with unlimited tissue penetration. Molecular imaging is a field by which specific targets or biological processes are imaged. MRI, which is used for functional imaging and for the diagnosis of a broad range of pathologic conditions, suffers from limited specificity and intrinsically low sensitivity. One possibility to alleviate partially ...