Structure Property Relationships of Carboxylic Acid Isosteres

P Lassalas, B Gay, C Lasfargeas…

Index: Jogi, Artur; Ilves, Marit; Paju, Anne; Pehk, Tonis; Kailas, Tiiu; Mueuerisepp, Aleksander-Mati; Lopp, Margus Tetrahedron Asymmetry, 2008 , vol. 19, # 5 p. 628 - 634

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Citation Number: 5

Abstract

... The importance of the carboxylic acid functional group in drug design is illustrated by the fact that >450 marketed drugs are carboxylic acid containing molecules.(5) However, the presence of this functional group in a drug or a drug candidate can be responsible for undesired ...