Tetrahedron Letters

One-pot synthesis of 1, 4-diarylsubstituted 1, 3-diynes from the sequential coupling reactions of aryl iodides and propiolic acid

Y Kim, A Park, K Park, S Lee

Index: Kim, Yong; Park, Ahbyeol; Park, Kyungho; Lee, Sunwoo Tetrahedron Letters, 2011 , vol. 52, # 15 p. 1766 - 1769

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Citation Number: 29

Abstract

1, 4-Disubstituted 1, 3-dialkynes were obtained from the one-pot palladium/copper- catalyzed coupling reactions of aryl iodide and propiolic acid. The optimized catalytic system consisted of 5.0 mol% Pd (PPh3) 2Cl2, 10mol% dppb, 10mol% CuI, 2.4 equiv of DBU, and 1.2 equiv of K2CO3. The coupling reaction was carried out at 30° C for 6h and subsequently at 80° C for 3h.

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