Anticholinesterasic, nematostatic and anthelmintic activities of pyridinic and pyrazinic compounds

…, JC Saldana, H Heinzen, L Domínguez…

Index: Valli; Danuello; Pivatto; Saldana; Heinzen; Dominguez; Campos; Marqui; Young; Viegas Jr.; Silva; Bolzani Current Medicinal Chemistry, 2011 , vol. 18, # 22 p. 3423 - 3430

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Citation Number: 8

Abstract

In the search for acetylcholinesterase inhibitors as a potential target for the discovery of anthelmintic drugs, a series of 27 pyridinic and pyrazinic compounds have been designed on the basis of molecular hybridization of two known AChE inhibitors, namely, tacrine and (-)- 3-O-acetylspectaline, and on the concept of isosterism. The synthesized compounds generally presented moderate anticholinesterasic activities when compared with the ...