Synthesis, activity, and molecular modeling studies of novel human aldose reductase inhibitors based on a marine natural product
JÁ de la Fuente, S Manzanaro, MJ Martín…
Index: Journal of Medicinal Chemistry, , vol. 46, # 24 p. 5208 - 5221
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Citation Number: 48
Abstract
... Journal of Medicinal Chemistry. ... 5,9-11 The most potent and better characterized orally active ARIs belong to two main chemical classes: (i) carboxylic acid derivatives, such as tolrestat, zopolrestat, and zenarestat, and (ii) spiro-hydantoins, such as sorbinil (Figure 1). ...
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[De La Fuente, Jesus Angel; Manzanaro, Sonia; Martin, Maria Jesus; De Quesada, Teresa G.; Reymundo, Isabel; Luengo, Santos M.; Gago, Federico Journal of Medicinal Chemistry, 2003 , vol. 46, # 24 p. 5208 - 5221]