Research on antibacterial and antifungal agents. VIII. synthesis and antimicrobial activity of 1, 4-diarylpyrroles

GC Porretta, M Biava, R Fioravanti, M Fischetti…

Index: Porretta; Biava; Fioravanti; Fischetti; Melino; Venza; Bolle; Tita European Journal of Medicinal Chemistry, 1992 , vol. 27, # 7 p. 717 - 722

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Citation Number: 7

Abstract

Abstract The synthesis and the antimicrobial activity of 1, 4-diarylpyrroles are reported. The obtained data in comparison with pyrrolnitrin show that many acid derivatives 4 exhibit a selective activity against some strains of Candida spp and poor activity against strains of Candida albicans. All ester derivatives 3 are inactive. The results obtained are discussed on the basis of structure-activity relationships.