Synthesis, biological evaluation and molecular docking studies of pyrazole derivatives coupling with a thiourea moiety as novel CDKs inhibitors

J Sun, XH Lv, HY Qiu, YT Wang, QR Du, DD Li…

Index: Sun, Jian; Lv, Xian-Hai; Qiu, Han-Yue; Wang, Yan-Ting; Du, Qian-Ru; Li, Dong-Dong; Yang, Yong-Hua; Zhu, Hai-Liang European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 1 - 9

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Citation Number: 17

Abstract

Abstract It was discovered that a number of cyclin dependent kinase inhibitors containing the pyrazole core structure exhibited high inhibitory potency against broad-range CDKs and corresponding anti-proliferative activities. This information guided us to design and synthesize a series of 1, 3-diphenyl-N-(phenylcarbamothioyl)-1H-pyrazole-4-carboxamide derivatives (5a–10d), and evaluate their biological activities as CDKs inhibitors. Among all ...