Tetrahedron

Application of the Pictet–Spengler reaction to aryl amine substrates linked to deactivated aromatic heterosystems

B Saha, S Sharma, D Sawant, B Kundu

Index: Saha; Sharma; Sawant; Kundu Tetrahedron, 2008 , vol. 64, # 37 p. 8676 - 8684

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Citation Number: 30

Abstract

Three new substrates with an aryl amine moiety attached to quinoxalines, triazoles and tetrazoles either via C or N have been used for the Pictet–Spengler reaction. The substrates have been designed by applying the concept of 'aryl amine attached to a deactivated heteroaromatic ring'in a manner to facilitate endo cyclization. This is in contrast to the substrates used traditionally and reported earlier by us that are based on either aliphatic ...