Powerful Approach to Heterocyclic Skeletal Diversity by Sequential Three-Component Reaction of Amines, Isothiocyanates, and 1, 2-Diaza-1, 3-dienes

OA Attanasi, S Bartoccini, G Favi, G Giorgi…

Index: Attanasi, Orazio A.; Bartoccini, Silvia; Favi, Gianfranco; Giorgi, Gianluca; Perrulli, Francesca Romana; Santeusanio, Stefania Journal of Organic Chemistry, 2012 , vol. 77, # 2 p. 1161 - 1167

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Citation Number: 12

Abstract

By highly efficient, one-pot, three-component reactions, combining one set of 1, 2-diaza-1, 3- dienes (DDs), primary amines, and isothiocyanates in a different sequential order of addition, heterocyclic skeletal diversity can be achieved. The key feature discriminating the different heterocyclic core formation is the availability of the N or S heteronucleophile to give the first Michael addition step affording regioselective substituted 2-thiohydantoins or 2- ...