Design, synthesis, biological evaluation and molecular modeling of 1, 3, 4-oxadiazoline analogs of combretastatin-A4 as novel antitubulin agents
Y Hu, X Lu, K Chen, R Yan, QS Li, HL Zhu
Index: Hu, Yang; Lu, Xiang; Chen, Ke; Yan, Ru; Li, Qing-Shan; Zhu, Hai-Liang Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 2 p. 903 - 909
Full Text: HTML
Citation Number: 34
Abstract
A total of 20 novel 1, 3, 4-oxadiazoline analogs (6a–6t) of combretastatin A-4 with naphthalene ring were designed, synthesized, and evaluated for biological activities as potential tubulin polymerization inhibitors. Among these compounds, 6n showed the most potent antiproliferative activities against multiple cancer cell lines and retained the microtubule disrupting effects. Docking simulation was performed to insert compound 6n ...
Related Articles:
[Avila, Carolina M.; Lopes, Alexandra B.; Gonalves, Arlan S.; Da Silva, Leandro L.; Romeiro, Nelilma C.; Miranda, Ana Luisa P.; Sant'Anna, Carlos M.R.; Barreiro, Eliezer J.; Fraga, Carlos A.M. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1245 - 1253]
Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents
[Carvalho, Samir A.; Feitosa, Larisse O.; Soares, Marcio; Costa, Thadeu E.M.M.; Henriques, Maria G.; Salomao, Kelly; De Castro, Solange L.; Kaiser, Marcel; Brun, Reto; Wardell, James L.; Wardell, Solange M.S.V.; Trossini, Gustavo H.G.; Andricopulo, Adriano D.; Da Silva, Edson F.; Fraga, Carlos A.M. European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 512 - 521]
Sur la β??naphtoyl??hydrazine et l'acide 3??hydrazino??2??naphtoïque
[Goldstein; Cornamusaz Helvetica Chimica Acta, 1932 , vol. 15, p. 939,943]