Reaction of Methyl Diazoacetate with Amines Catalyzed by Ru2 (OAc) 4Cl

AV Maidanova, AD Bakeeva, RM Sultanova…

Index: Maidanova; Bakeeva; Sultanova; Biglova; Dokichev Russian Journal of Organic Chemistry, 2010 , vol. 46, # 10 p. 1461 - 1465

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Abstract

Abstract Reactions of primary and secondary amines with methyl diazoacetate in the presence of Ru 2 (OAc) 4 Cl gave the corresponding N-substituted glycine methyl esters in almost quantitative yield. Catalytic decomposition of methyl diazoacetate generates methoxycarbonylcarbene which is inserted into the NH bond of amines with high regioselectivity.

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