One??Pot Chemoselective Bis (Suzuki–Miyaura Cross??Coupling): Efficient Access to 3, 9??Bis [(hetero) aryl]??4H??pyrido [1, 2??a] pyrimidin??4??one Derivatives Under …

…, MD Crozet, N Primas, P Vanelle

Index: Kabri, Youssef; Crozet, Maxime D.; Primas, Nicolas; Vanelle, Patrice European Journal of Organic Chemistry, 2012 , # 28 p. 5595 - 5604

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Citation Number: 5

Abstract

Abstract A one-pot chemoselective bis (Suzuki–Miyaura cross-coupling) reaction under microwave irradiation is reported for the 4H-pyrido [1, 2-a] pyrimidin-4-one series. First, we ascertained an initial coupling reaction that was selectively carried out at the C-3 position of (7, 9-dichloro-3-iodo-4-oxo-4H-pyrido [1, 2-a] pyrimidin-2-yl) methyl acetate (4). Next, we developed an extremely efficient one-pot chemoselective bis (Suzuki–Miyaura cross- ...