Synthesis and in vitro screening of novel N-benzyl aplysinopsin analogs as potential anticancer agents

NR Penthala, TR Yerramreddy, PA Crooks

Index: Penthala, Narsimha Reddy; Yerramreddy, Thirupathi Reddy; Crooks, Peter A. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1411 - 1413

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Citation Number: 12

Abstract

A series of novel substituted (Z)-5-((1-benzyl-1H-indol-3-yl) methylene) imidazolidin-2, 4- diones (3a–f) and (Z)-5-((1-benzyl-1H-indol-3-yl) methylene)-2-iminothiazolidin-4-ones (3g– o) have been synthesized utilizing microwave irradiation. These analogs were evaluated for in vitro cytotoxicity against a panel of 60 human tumor cell lines. Compound 3i exhibits potent growth inhibition against melanoma UACC-257 (GI50= 13.3 nM) and OVCAR-8 ...

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