Synlett
Metallation versus heteroatom lithium complexation: Mono-and dilithiation of dipyridylpiperazines
F Louërat, PC Gros, Y Fort
Index: Louerat, Frederic; Gros, Philippe C.; Fort, Yves Synlett, 2006 , # 9 p. 1379 - 1383
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Citation Number: 10
Abstract
Abstract BuLi-LiDMAE induced the efficient lithiation of dipyridylpiperazines despite strong competing lithium coordination by several nitrogen atoms. Symmetrical substrates led to a one-pot dilithiation while dissymmetrical species gave mono-or dilithiation under temperature control.
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