Synthesis and binding affinities of a series of 1, 2-benzisoxazole-3-carboxamides to dopamine and serotonin receptors

A Nuhrich, M Varache-Lembege, J Vercauteren…

Index: Nuhrich; Varache-Lembege; Vercauteren; Dokhan; Renard; Devaux European Journal of Medicinal Chemistry, 1996 , vol. 31, # 12 p. 957 - 964

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Citation Number: 17

Abstract

A series of 1, 2-benzisoxazole-3-carboxamides derived from tertiary cycloalkylamines was synthesized and evaluated for affinity for serotonergic (5-HT3 and 5-HT4) and dopaminergic (D2) receptors using radioligand binding assays. The majority of compounds displayed a very weak affinity for the studied neurotransmitter receptors. Only amides containing a conformationally rigid system retained a relative 5-HT3 receptor affinity. The presence of a ...