Synthesis of 3H??Quinazolin??4??ones and 4H??3, 1??Benzoxazin??4??ones via Benzylic Oxidation and Oxidative Dehydrogenation using Potassium Iodide??tert??Butyl …
…, CU Maheswari, S Ghantasala, C Jyothi…
Index: Kumar, R. Arun; Maheswari, C. Uma; Ghantasala, Satheesh; Jyothi; Reddy, K. Rajender Advanced Synthesis and Catalysis, 2011 , vol. 353, # 2-3 p. 401 - 410
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Citation Number: 49
Abstract
Abstract A simple and elegant method for benzylic activation was demonstrated employing the potassium iodide/tert-butyl hydrogen peroxide catalytic system. This methodology was further extended for the synthesis of biologically important heterocycles namely, 3H- quinazolin-4-ones and 4H-3, 1-benzoxazin-4-ones including mecloqualone and etaqualone which are important quinazolinone-based drugs used for the treatment of insomnia in ...
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