Disruption of fibres from the AcPHF6 tau model by naturally occurring aurones and synthetic analogs

…, M Peuchmaur, A Boumendjel…

Index: Souard, Florence; Okombi, Sabrina; Beney, Chantal; Chevalley, Severine; Valentin, Alexis; Boumendjel, Ahcne Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 15 p. 5724 - 5731

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Abstract

The formation of tau aggregates is strongly linked to the neurodegenerative process in tauopathies such as Alzheimer's disease (AD). Yet only a few molecules have shown to efficiently prevent the in vitro formation of those aggregates, and the identification of such