Synthesis, antibacterial screening, and POM analyses of novel bis-isoxazolyl/pyrazolyl-1, 3-diols

H Juneja, D Panchbhai, J Sheikh, V Ingle…

Index: Juneja, Harjeet; Panchbhai, Dhanashri; Sheikh, Javed; Ingle, Vishwas; Hadda, Taibi Ben Medicinal Chemistry Research, 2014 , vol. 23, # 3 p. 1537 - 1547

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Citation Number: 7

Abstract

Abstract This research article reports the synthesis of 4, 6-bis (5-aryl/heteroaryl-1, 2-oxazol-3- yl) benzene-1, 3-diol 4a–4f and 4, 6-bis (5-aryl/heteroaryl-1 H-pyrazol-3-yl) benzene-1, 3- diol 5a–5f from 1, 1′-(4, 6-dihydroxybenzene-1, 3-diyl) bis (3-aryl/heteroarylpropane-1, 3- dione) 3a–3f. The compounds were fully characterized using spectroscopic analyses and tested for their antibacterial activity. A correlation of structure and activities relationship of ...