Synthesis of Potential Diuretic Agents. II. Dichloro Derivatives of 1, 2, 4-Benzothiadiazine 1, 1-Dioxide1

JH Short, U Biermacher

Index: Short,J.H.; Biermacher,U. Journal of the American Chemical Society, 1960 , vol. 82, p. 1135 - 1138

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Citation Number: 14

Abstract

The following were allowed to react with chlorosulfonic acid, and the resulting sulfonyl chlorides converted to the corresponding sulfonamides: 2, 3-dichloro-, 2, 5-dichloro-, 3, 4- dichloro-and 3, 5-dichloroaniline. Except for 2, 5-dichloroaniline, which did not sulfonate in the position ortho to the amino group, the sulfonamides were cyclized with formic acid, and also with formaldehyde, to obtain substituted 1, 2, 4-benzothiadiazine 1, l-dioxides. ...