Copper-catalyzed CuAAC/intramolecular C–H arylation sequence: Synthesis of annulated 1, 2, 3-triazoles

R Jeyachandran, HK Potukuchi…

Index: Jeyachandran, Rajkumar; Potukuchi, Harish Kumar; Ackermann, Lutz Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1771 - 1777,7

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Citation Number: 21

Abstract

Abstract Step-economical syntheses of annulated 1, 2, 3-triazoles were accomplished through copper-catalyzed intramolecular direct arylations in sustainable one-pot reactions. Thus, catalyzed cascade reactions involving [3+ 2]-azide–alkyne cycloadditions (CuAAC) and C–H bond functionalizations provided direct access to fully substituted 1, 2, 3-triazoles with excellent chemo-and regioselectivities. Likewise, the optimized catalytic system ...

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Copper-catalyzed CuAAC/intramolecular C–H arylation sequence: Synthesis of annulated 1, 2, 3-triazoles

Abstract

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