Journal of medicinal chemistry

Iodophenyl derivatives of. alpha.-methyl alanine and isovaline as potential oral cholecystographic agents

G Shtacher, S Dayagi

Index: Shtacher,G.; Dayagi,S. Journal of Medicinal Chemistry, 1972 , vol. 15, p. 1174 - 1177

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Citation Number: 5

Abstract

Gastrointestinal absorption as well as gall bladder accumula tion are prime factors in determining the efficacy of oral cholecystographic agents. In this connection, the biological properties of a-aminoisobutyric acid (AIB; 2-methylalanine), are of particular interest. AIB is a nonmetabolizable amino acid,'which undergoes active intestinal transport against a concentration gradient'and accumulates in the liver. 3 Since the presence of iodine atoms ...