Diuretics. 6-Substituted 3-Ketoalkyl-3, 4-dihydro-2H-1, 2, 4-benzothiadiazine 1, 1-Dioxides and Related Anils, Oximes, and Hydrazones1

JE Robertson, DA Dusterhoft…

Index: Robertson,J.E. et al. J. Med. Chem., 1965 , vol. 8, p. 90 - 95

Full Text: HTML

Citation Number: 7

Abstract

Condensation of: Lppropriat. e ketoaldehydeu with 5-substituted L', I-disulfan~ ylanilirles under ac3id c% t: tlysia provided n group of B-substitut, ed 3, 4-dihydro-2H-l,~, 4-l, enzclthiadiazine-7-sulf1:~ namide 1, l-dioxides containing: I-ketoalkyl substituents. When 0- ketoaldehydes were used arid the 2-sulfamgl group was at least monosnilstituted, either the usual ring-closure products or isomeric enol-mils were isolated depending on reaction ...